CS231221B1 - L-alanyl-d-isoglutamine adamantylamide - Google Patents

L-alanyl-d-isoglutamine adamantylamide Download PDF

Info

Publication number
CS231221B1
CS231221B1 CS824908A CS490882A CS231221B1 CS 231221 B1 CS231221 B1 CS 231221B1 CS 824908 A CS824908 A CS 824908A CS 490882 A CS490882 A CS 490882A CS 231221 B1 CS231221 B1 CS 231221B1
Authority
CS
Czechoslovakia
Prior art keywords
mdp
adp
isoglutamine
effects
alanyl
Prior art date
Application number
CS824908A
Other languages
Czech (cs)
English (en)
Other versions
CS490882A1 (en
Inventor
Martin Flegel
Milan Krojidlo
Jiri Kolinsky
Karel Masek
Jaroslav Seifert
Original Assignee
Martin Flegel
Milan Krojidlo
Jiri Kolinsky
Karel Masek
Jaroslav Seifert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Martin Flegel, Milan Krojidlo, Jiri Kolinsky, Karel Masek, Jaroslav Seifert filed Critical Martin Flegel
Priority to CS824908A priority Critical patent/CS231221B1/cs
Priority to JP58112956A priority patent/JPS5931745A/ja
Priority to DD83252412A priority patent/DD217210A1/de
Priority to EP83106342A priority patent/EP0098520B1/de
Priority to MX197864A priority patent/MX156864A/es
Priority to AT83106342T priority patent/ATE17652T1/de
Priority to US06/509,293 priority patent/US4515715A/en
Priority to HU832364A priority patent/HU194911B/hu
Priority to DE8383106342T priority patent/DE3362009D1/de
Publication of CS490882A1 publication Critical patent/CS490882A1/cs
Publication of CS231221B1 publication Critical patent/CS231221B1/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CS824908A 1982-06-29 1982-06-29 L-alanyl-d-isoglutamine adamantylamide CS231221B1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CS824908A CS231221B1 (en) 1982-06-29 1982-06-29 L-alanyl-d-isoglutamine adamantylamide
JP58112956A JPS5931745A (ja) 1982-06-29 1983-06-24 Ｌ―アラニル―ｄ―イソグルタミンアダマンチルアミド及びその製造方法
DD83252412A DD217210A1 (de) 1982-06-29 1983-06-27 Verfahren zur herstellung von l-alanyl-d-isoglutaminyl-adamantylamid
EP83106342A EP0098520B1 (de) 1982-06-29 1983-06-29 L-Alanyl-D-isoglutaminyl-adamantylamid, Verfahren zu seiner Herstellung und pharmazeutische Mittel mit dieser Verbindung
MX197864A MX156864A (es) 1982-06-29 1983-06-29 Procedimiento para preparar adamantilamida de l-alanil-d-isoglutamina
AT83106342T ATE17652T1 (de) 1982-06-29 1983-06-29 L-alanyl-d-isoglutaminyl-adamantylamid, verfahren zu seiner herstellung und pharmazeutische mittel mit dieser verbindung.
US06/509,293 US4515715A (en) 1982-06-29 1983-06-29 L-Alanyl-D-isoglutamine adamantylamide
HU832364A HU194911B (en) 1982-06-29 1983-06-29 Process for preparing l-alanyl-d-isoglutaminyl-adamantyl-amide and pharmaceuticals comprising these compounds
DE8383106342T DE3362009D1 (en) 1982-06-29 1983-06-29 L-alanyl-d-isoglutaminyl-adamantyl amide, process for its preparation and pharmaceutical compositions containing this compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS824908A CS231221B1 (en) 1982-06-29 1982-06-29 L-alanyl-d-isoglutamine adamantylamide

Publications (2)

Publication Number Publication Date
CS490882A1 CS490882A1 (en) 1984-02-13
CS231221B1 true CS231221B1 (en) 1984-10-15

Family

ID=5392849

Family Applications (1)

Application Number Title Priority Date Filing Date
CS824908A CS231221B1 (en) 1982-06-29 1982-06-29 L-alanyl-d-isoglutamine adamantylamide

Country Status (9)

Country Link
US (1) US4515715A (en])
EP (1) EP0098520B1 (en])
JP (1) JPS5931745A (en])
AT (1) ATE17652T1 (en])
CS (1) CS231221B1 (en])
DD (1) DD217210A1 (en])
DE (1) DE3362009D1 (en])
HU (1) HU194911B (en])
MX (1) MX156864A (en])

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS231221B1 (en) * 1982-06-29 1984-10-15 Martin Flegel L-alanyl-d-isoglutamine adamantylamide
FR2572399B1 (fr) * 1984-10-31 1987-01-16 Panmedica Sa Nouveaux derives de l'adamantanamine, leurs procedes de preparation et medicaments les contenant
YU30589A (en) * 1989-02-09 1991-10-31 Imunoloski Z Zagreb New adamantyl containing tripeptides and it's hydrochloride and process for preparing and use
IT1264129B1 (it) * 1993-04-09 1996-09-16 Codev S A Peptidi ad attivita' immunomodulatoria derivati da frammenti di leucochinina
WO2000068251A1 (en) 1999-05-07 2000-11-16 The University Of Virginia Patent Foundation Biological production of stable glutamine, poly-glutamine derivatives in transgenic organisms and their use for therapeutic purposes
CN1930183B (zh) * 2003-08-13 2010-12-29 康哲医药研究(深圳)有限公司 包含苯丙氨酰-谷氨酸及苯丙氨酰-谷氨酰-谷氨酸的生物活性肽

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2482957A2 (fr) * 1979-06-29 1981-11-27 Rhone Poulenc Ind Nouveaux dipeptides, leur preparation et les medicaments qui les contiennent
US4273704A (en) * 1979-12-03 1981-06-16 G. D. Searle & Co. N-Adamantane-substituted tetrapeptide amides
CS231221B1 (en) * 1982-06-29 1984-10-15 Martin Flegel L-alanyl-d-isoglutamine adamantylamide

Also Published As

Publication number Publication date
JPH0352478B2 (en]) 1991-08-12
DE3362009D1 (en) 1986-03-13
MX156864A (es) 1988-10-07
DD217210A1 (de) 1985-01-09
JPS5931745A (ja) 1984-02-20
ATE17652T1 (de) 1986-02-15
CS490882A1 (en) 1984-02-13
EP0098520B1 (de) 1986-01-29
HU194911B (en) 1988-03-28
US4515715A (en) 1985-05-07
EP0098520A1 (de) 1984-01-18

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